Neurological Complication
Conditions
Brief summary
Non-invasive neuromonitoring tools such as transcranial doppler, optic nerve envelope diameter measurement and quantitative pupillometry are routinely used in acute brain injured patients as part of multimodal neuromonitoring with the aim, among others, of detecting episodes of intracranial hypertension, each method allowing the study of one of the different pathophysiological mechanisms of its impact. However, at present there is no data in the literature on the value of these non-invasive neuromonitoring tools in the management of patients undergoing controlled intracranial surgery. The study aims to help the early detection of postoperative neurological deterioration.
Interventions
OTHERNon-invasive neuromonitoring evaluation (transcranial doppler, optic nerve envelope diameter and quantitative pupillometry)
4 days Post-operation follow-up. Data will be gathered before the surgery and at regular times after the surgery until day 4
Sponsors
Centre Hospitalier Universitaire de la Réunion
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Regulated intracranial surgery: scheduled \> 48 hours * French-speaking patient * No opposition from the patient or a relative when the patient is unable to consent
Exclusion criteria
* Chronic subdural haematoma * Isolated cerebral endovascular procedure * Stereotactic biopsy * Scheduled ventriculoperitoneal shunt or isolated ventriculocisternostomy * Specific non-inclusion criteria for quantitative pupillometry: known pupillary abnormalities, glaucoma, cataract surgery and any ocular surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evolution of non-invasive neuromonitoring measures (using transcranial doppler) | From 1 hour before the surgery until Day 4 post-surgery | This emasure will be performed bilaterally at the level of the first part of the middle cerebral artery, the values collected will be: * Systolic, mean and diastolic velocities; pulsatility index * Estimation of intracranial pressure |
| Evolution of non-invasive neuromonitoring measures (optic nerve envelope diameter) | From 1 hour before the surgery until Day 4 post-surgery | The diameter of the optic nerve envelope will be collected bilaterally using an ultrasound machine |
| Evolution of non-invasive neuromonitoring measures (quantitative pupillometry) | From 1 hour before the surgery until Day 4 post-surgery | The values collected will be : \- Size, quantification of the amplitude of variation to light, latency and speed of constriction of the pupil, presence or absence of anisocoria (defined by a difference \>1mm in size between the two pupils) |
Countries
Reunion
Contacts
CONTACTRomain ASMOLOV, MD
CONTACTLaetitia BERLY, PhD
PRINCIPAL_INVESTIGATORRomain ASMOLOV, MD
CHU de la Réunion
Outcome results
None listed