Cancer, Neoplasms
Conditions
Brief summary
Early diagnosis of cancer may provide patients with more treatment options and hopefully prolong survival. The purpose of this multi-center study is to collect peripheral blood from newly diagnosed cancer patients and healthy donors to establish a blood cell RNA-based model for the differentiation of cancer patients and healthy donors. The area under the receiver operating characteristic (AUROC), sensitivity and specificity of the test in the early detection of multiple cancers will be measured.
Interventions
DIAGNOSTIC_TESTBlood test
RNA sequencing of peripheral blood cells
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
for All the Participants 1. Age 18 years or older 2. Provide informed consent
Exclusion criteria
for All the Participants: 1. Pregnancy or lactating women 2. Received a blood transfusion within 1 month 3. Received anti-cancer treatment within 3 years 4. Known prior diagnosis of cancer 5. Poor health status or unfit to tolerate blood draw
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity and specificity of cancer detection | 1 year | Sensitivity and specificity of the early detection of 30 types of cancers of a blood cell RNA-based cancer detection test |
| Accuracy of TOO prediction | 1 year | Accuracy of the tissue of origin (TOO) prediction of a blood cell RNA-based cancer detection test |
Countries
China
Contacts
Primary ContactZheng Wang, MD/PhD
Backup ContactLuming Xu
Outcome results
None listed