Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic

Mechanisms of Left Ventricular Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Conditions of the Arctic Region

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05839028

Enrollment

550

Registered

2023-05-03

Start date

2022-10-16

Completion date

2026-10-30

Last updated

2026-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure With Preserved Ejection Fraction

Keywords

hypertension, Arctic, rotational shift work, echocardiography

Brief summary

The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.

Detailed description

Hypothesis: In patients with hypertension working in the conditions of the Arctic shift, the combination of climatic and geographical factors and rotational expeditionary method of labor contributes to the increase in the left ventricular remodeling processes and leads to the formation of heart failure with preserved ejection fraction.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* The patient signed the informed consent

Exclusion criteria

* Valvular pathology of the heart * Past cardiac or cerebral complications * Identified heart rhythm disturbances * Coronary heart disease * Patients with severe somatic pathology, whose prognostic survival rate does not exceed 1 year * The presence of a mental disorder of organic origin

Design outcomes

Primary

Measure	Time frame	Description
Echocardiographic assessment of GLS (Global longitudinal strain), %	One year	Echocardiographic assessment of global strain (%) at baseline and after one year of follow-up.

Secondary

Measure	Time frame	Description
Concentration of Myeloperoxidase, ug/mL	One year	Concentration of oxidative stress biomarker, myeloperoxidase, is assessed using Lab analyzer Stat Fax 4200 (USA).
Concentration of oxidized low density lipoproteins, CU	One year	Concentration of oxidative stress biomarker, oxidized low density lipoproteins, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of homocysteine, umol/L	One year	Concentration of oxidative stress biomarker, homocysteine, is assessed using Lab analyzer - IMMULITE 2000 (Siemens Diagnostics, USA).
Concentration of C-reactive protein, IU/L	One year	Concentration of immune inflammation biomarker, C-reactive protein, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of tumor necrosis factor alpha, pg/ml	One year	Concentration of immune inflammation biomarker, tumor necrosis factor alpha is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of 1,6,8 interleukins, pg/mL	One year	Concentration of immune inflammation biomarker, (1,6,8) interleukin, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of GDF-15/MIC-1 (Growth Differentiation Factor 15/Macrophage-inhibitory 1), pg/mL	One year	Concentration fibrosis biomarker, GDF-15/MIC-1, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of PIIINP (N-terminal propeptide to procollagen III), ng/mL	One year	Concentration of fibrosis biomarker, PIIINP, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of FGF-23 (Fibroblast growth factor 23), pmol/L	One year	Concentration of fibrosis biomarker, FGF-23, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of plasma procollagen type 3, CU	One year	Concentration of remodeling factor biomarker, plasma procollagen type 3, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of adrenaline, pg/mL	One year	Concentration of catecholamine, adrenaline, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of noradrenaline, pg/mL	One year	Concentration of catecholamine, noradrenaline, is assessed using Lab analyzer - Stat Fax 4200 (USA);
Concentration of testosterone, nmol/L	One year	Concentration of hormone, testosterone, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of progesterone, nmol/L	One year	Concentration of hormone biomarker, progesterone, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of estradiol, pg/mL	One year	Concentration of hormone, estradiol, is assessed using Lab analyzer - Stat Fax 4200 (USA).
Concentration of cystatin-C, ng/mL	One year	Concentration of chronic kidney disease biomarker, cystatin-C, is assessed by Lab analyzer - Stat Fax 4200 (USA).
Concentration of NGAL (Neutrophilic gelatinase-associated lipocalin or neutrophilic lipocalin), ng/mL	One year	Concentration of chronic kidney disease biomarker, NGAL, is assessed by Lab analyzer - Stat Fax 4200 (USA).

Countries

Russia

Contacts

PRINCIPAL_INVESTIGATORLiudmila Gapon, MD, PhD

Tyumen Cardiology Research Center

Outcome results