Primary Tumor Burden Score:A Novel Staging Parameter for ESCC After nCRT

Primary Tumor Burden Score: A Novel Staging Parameter Superior to ypT-category for Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemoradiotherapy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05839002

Enrollment

187

Registered

2023-05-03

Start date

2010-05-21

Completion date

2023-03-15

Last updated

2023-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neoplasm, Esophagus, Neoplasm, Squamous Cell

Brief summary

In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS).

Detailed description

In this case-only study, the investigators try to define a novel staging parameter, the Primary Tumor Burden Score (PTBS), which will combine the proportion of residual primary tumor cells and pre-treatment pathological T stage (prepT stage). The investigators will also try to improve ypTNM stage by results of PTBS.

Interventions

PROCEDUREnCRT

ESCC patients that recieved surgery and nCRT.

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 79 Years

Healthy volunteers

Inclusion criteria

\- Neoadjuvant chemoradiotherapy and surgical resection of esophageal squamous cell carcinoma

Exclusion criteria

* Patients receiving neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma without surgical resection

Design outcomes

Primary

Measure	Time frame	Description
Five-year survival of patients	From surgery to the end of follow-up(at least 5 years later)	The survival of the patients was recorded by follow-up for five years after surgery.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026