Life Style
Conditions
Keywords
exercise, circadian system, physical activity, glucose tolerance, blood pressure
Brief summary
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: * complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples
Detailed description
The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.
Interventions
BEHAVIORALExercise intervention
Research participants will be assigned to two exercise conditions.
Sponsors
Brigham and Women's Hospital
National Heart, Lung, and Blood Institute (NHLBI)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-45 yr old * Body mass index (BMI) 18.5 - 34.9 kg/m2 * No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) * Willing to adhere to the protocol requirements for the duration of the study
Exclusion criteria
* Currently smoking/vaping or 5 or more years of smoking/vaping * Currently pregnant or breastfeeding * History of drug or alcohol dependency * History of psychiatric illness or disorder * Any hospitalization due to COVID-19 * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| glucose level | 24-hour test period after exercise | mean glucose level after exercise session |
| mean arterial pressure | 24-hour test period after exercise | mean arterial pressure after exercise session |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| insulin sensitivity index | about 12 and 24 hours after exercise | Oral Minimal Model method estimates mean insulin sensitivity based on blood glucose and insulin levels from two mixed meal tests after exercise session |
| beta-cell function index | about 12 and 24 hours after exercise | Oral Minimal Model method estimates mean beta-cell function based on blood glucose, insulin and c-peptide levels from two mixed meal tests after exercise session |
| total peripheral resistance | 24-hour test period after exercise | total peripheral resistance derived from BP waveform measured by finger plethysmography |
| autonomic nervous system activity | 24-hour test period after exercise | derived by time-domain heart rate variability analysis |
Countries
United States
Contacts
CONTACTJingyi Qian, PhD
CONTACTVy Nguyen, B.S.
PRINCIPAL_INVESTIGATORJingyi Qian, PhD
Brigham and Women's Hospital
Outcome results
None listed