Alzheimer's Disease, Sleep Disturbance
Conditions
Brief summary
Aim 2 will investigate the effect of 3 different light exposure lengths on sleep, mood and agitation in persons with Alzheimer's disease. Participants will be randomly assigned to one of three conditions of light exposure: 1) 2-h morning light exposure; 2) 4-h morning light exposure; and 3) all day light exposure.
Interventions
Lighting intervention using high light levels designed to effect the circadian system
Lighting intervention using low light levels designed to not effect the circadian system
Sponsors
Icahn School of Medicine at Mount Sinai
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of Alzheimer's disease or related dementia with a Montreal Cognitive Assessment score \<25 * Sleep disturbance with a Pittsburgh Sleep Quality Index score ≥5
Exclusion criteria
* Extensive brain vascular disease, traumatic brain injury, multiple sclerosis, Parkinson's Disease * Obstructing cataracts * Severe macular degeneration * Use of sleep medication * Use of oral melatonin * untreated moderate to severe sleep apnea * Severe restless leg syndrome * Blindness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sleep Disturbance using the Pittsburgh Sleep Quality Index | up to week 14 | The PSQI is used to measure sleep quality and is composed of 19 items that generate 7 component scores (subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction). Each subscale is scored 0 to 3. The sum of the 7 component scores yields a single global score with a range of 0 to 21. A higher score indicates higher sleep disturbance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sleep efficiency using actigraphy | up to week 14 | Actigraphs will be worn continuously for 7 days during each assessment week. Changes in sleep efficiency will be measured using the actigraphy software. Sleep efficiency is a calculated as a ratio of the time spent in bed and the time spent sleeping. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMariana Figueiro, PhD
Icahn School of Medicine at Mount Sinai
Outcome results
None listed