Hepatocellular Carcinoma
Conditions
Keywords
Hepatocellular Carcinoma, Tumor micronecrosis, Nomogram
Brief summary
The heterogeneity of hepatocellular carcinoma (HCC) leads to the unsatisfying predicting performance of current staging systems. HCC patients with pathological tumor micronecrosis have immunosuppressive microenvironment. We aimed to develop novel prognostic models by integrating micronecrosis to more precisely predict the survival of HCC patients after hepatectomy.
Interventions
OTHERobserving whether HCC patients having tumor micronecrosis
whether HCC patients having tumor micronecrosis or not
Sponsors
Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. pathologically diagnosed as HCC; 2. curative hepatectomy with R0 resection; 3. conserved liver function with Child Pugh class A or B
Exclusion criteria
1. with macrovascular invasion or extrahepatic metastasis; 2. receiving other anti-tumor treatments such as TACE or systemic drugs; 3. with other primary cancers; 4. incomplete follow-up data; 5. without sufficient formalin-fixed, paraffin-embedded (FFPE) specimens for micronecrosis evaluation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Harrell concordance index (C-index) | Up to 5 years |
Secondary
| Measure | Time frame |
|---|---|
| the time-dependent area under the receiver operating characteristic curve(tdAUROC) | Up to 5 years |
Countries
China
Contacts
Primary ContactTingbo Liang, PhD
Backup ContactQi Zhang, MD
Outcome results
None listed