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Immediate Suboptimal Result of Mitral Valve Repair: Late Implications in a Matched Cohort Study

Immediate Suboptimal Result of Mitral Valve Repair: Late Implications in a Matched Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05836480
Enrollment
141
Registered
2023-05-01
Start date
2019-10-05
Completion date
2019-10-15
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mitral Regurgitation

Brief summary

Mitral valve regurgitation is a pathology affecting the left atrioventricular valve, conditioning the loss of the normal unidirectionality of the atrioventricular flow and therefore volumetric and pressure overload of the left heart chambers. In industrialized countries, the most common etiology of mitral regurgitation is degenerative mitral disease. Mitral valve repair surgery represents the gold standard for the treatment of severe degenerative mitral regurgitation. The expected optimal result would be the absence of residual post-procedural mitral regurgitation, even if it is not uncommon to obtain a valve with residual regurgitation of a mild degree. In some cases, for various reasons (technical difficulties, long aortic clamping time, advanced age, high pre-operative surgical risk), a suboptimal result is accepted, i.e. a post-procedural residual mitral regurgitation of even a moderate degree ( 0, 1+, or 2+/4+). The aim of the present study is to evaluate the late clinical and echocardiographic implications of suboptimal mitral valve repair with a paired-data cohort study

Interventions

conservative surgery to treat mitral regurgitation. A mitral valve plasty is performed according to the most appropriate technique

Sponsors

Michele De Bonis
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Study group: * presence of severe degenerative mitral regurgitation treated by mitral valve repair between 2006 and 2013; * presence of moderate residual mitral regurgitation at discharge. * Control group: * presence of severe degenerative mitral regurgitation treated by mitral valve repair between 2006 and 2013; * presence of residual mitral regurgitation of at least mild grade at discharge.

Exclusion criteria

* none

Design outcomes

Primary

MeasureTime frame
Mortalitythrough study completion, a minimum of 6 years

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026