Post-COVID-19 Syndrome
Conditions
Keywords
persistent headache
Brief summary
Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system. We investigate cpost-COVID-19 patients with persistent headache lasting longer than 3 weeks, to hospitalized acute COVID-19 patients with neurological symptoms and to other non-COVID-19 disease-controls. Readout are neurologial and glial biomarkers in CSF.
Detailed description
Measurements of neuronal and glial markers in CSF were performed on a SIMOA analyzer (Quanterix) using the Neurology 4-Plex A (Nf-L, Tau, GFAP, UCH-L1) kit.
Interventions
OTHERno intervention
no intervention
Sponsors
University Hospital, Bonn
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of COVID, Parkinson's disease, primary headache, Multiples Sclerosis, facial paralysis * Persistent post-COVID-19 headache after 3 months of infection * Post COVID-patients without persistent headache * must be able to perform lumbar puncture
Exclusion criteria
* unknown history of COVID infection * lumbar puncture not possible
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biomarker analysis in CSF | after 3 months of initial infection | Levels of Nf-L, Tau, GFAP, UCH-L1 in CSF |
Countries
Germany
Outcome results
None listed