Carotid Stenosis
Conditions
Brief summary
The aim of the study is to evaluate changes in retinal function by means of electro-functional examinations of the retina and to associate them with any changes in chorioretinal vascular density occurring in the ipsilateral eye after carotid revascularization surgery.
Interventions
DIAGNOSTIC_TESTOptical coherence tomography angiography and pattern electroretinogram
Optical coherence tomography angiography is an infrared eye scan that analyzes retinal vascularization and anatomy
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>18 years old * Carotid stenosis diagnosis with indication to perform carotid endarterectomy * informed consent form signing
Exclusion criteria
* age \<18 years old * recurrent intraocular inflammation * retinal disease * optic neuropathy, optic nerve drusen, opacity of the dioptric means in the pre- or post-operative period that prevents the acquisition of high-resolution images * unstable fixation * spheric refractive error \> +/- 6 D spheric and/or +/- 3 D cylinder * history of prior ocular surgery * refusal of signing informed consent form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional retinal changes | 1 week and 3 months | To evaluate rate of pattern electroretinography/pattern visual evoked potential improvement in both eyes before and after carotid endarterectomy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Retinal vascular density changes | 1 week and 3 months | To evaluate rate of chorioretinal vascular density improvement trough angiographic optical coherence tomography before and after carotid endarterectomy |
Countries
Italy
Contacts
Primary ContactAntonio Baldascino, MD
Outcome results
None listed