Magnetoencephalography, Optical Pump Magnetometer, Neonate, Premature
Conditions
Keywords
Magnetoencephalography, optical pump magnetometer, neonate, Premature
Brief summary
MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling. The purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from a priori obtained by the classical technique of High Resolution EEG performed.
Interventions
40 minutes of Magnetoencephalography with Optical Pump Magnetometer
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
1 Days to No maximum
Healthy volunteers
Yes
Inclusion criteria
* For healthy adult volunteers * Age between 18 and 65 * No pathology, no treatment * No toxicant intake * For term newborns * Child between 38 and 42 weeks gestational age on the day of registration * No pathology, no treatment * For children born prematurely * Child between 28 and 36 weeks gestational age on the day of registration * No pathology, no treatment apart from routine care related to prematurity * For pregnant women * Pregnant with between 28 to 40 weeks gestational age on the day of registration * No pathology, no treatment
Exclusion criteria
* Subject and Patients not compatible MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible. * Patients who cannot stand to stand still for a few minutes. * Newborn on ventilatory assistance or infusion * Newborn baby not meeting the age criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Signal to noise ratio of the MEG OPM | 1 day | Signal to noise ratio of the MEG OPM is in dB |
| Signal to noise ratio of HR EEG | 1 day | Signal to noise ratio of HR EEG is in dB |
| Number of dB between Signal to noise ratio of the MEG OPM and Signal to noise ratio of HR EEG | 1 day | — |
Countries
France
Contacts
Primary ContactFabrice Wallois, Pr
Outcome results
None listed