Gasdermin D Levels in Preterm Labor
Conditions
Keywords
gasdermin D, preterm labor, pyroptosis
Brief summary
In this study, the investigators aimed to investigate the relationship between Gasdermin D levels measured from the maternal serum of patients diagnosed with preterm labor and spontaneous preterm labor in pregnant women.
Detailed description
This prospective case- control study was conducted between 15 July 2021 and 15 July 2022 at Bursa Yüksek İhtisas Training and Research Hospital. The study was conducted with pregnant women between the ages of 18-45 who were idiopathic preterm labor. Pregnant women between the ages of 18-45 who were diagnosed with preterm labor between 24-37 weeks of gestational were included. This study was conducted with 160 pregnant women who were diagnosed with idiopathic preterm labor and 167 healthy pregnant women who were in the same gestational week as these pregnant women and were not diagnosed with preterm labor. Group 1 patients diagnosed with preterm labor between 24-37 weeks( study group) (n:160), Group 2 consisted of healthy pregnant women who were not diagnosed with preterm labor between 24-37 weeks ( control group) (n: 167) . In group 1, 80 patients were diagnosed with early preterm (between 24-34 weeks ) and 80 patients with late preterm labor (34-36+6 weeks).
Interventions
OTHERGasdermin-d
Maternal serum Gasdermin-D levels in preterm labor and healthy pregnant women.
Sponsors
Sanliurfa Mehmet Akif Inan Education and Research Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Gastermin D and Pentaxin 3 levels were measured in the patients participating in the study. These are not routinely checked markers. Participants were assigned prospectively to an intervention or interventions according to a protocol to evaluate the effect of the intervention(s) on preeclampsia or HELLP related outcomes. Due to this, our work is interventional.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women who were diagnosed with idiopathic preterm labor and gave birth in our hospital * Pregnant women without vaginal infection * Healthy pregnant women between 24-37 weeks without a diagnosis of preterm labor
Exclusion criteria
* Multiple pregnancies * Pregnant women with a prediagnosis of chromosomal and congenital anomalies in the fetus * Women with a known infective or autoimmune disease before pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| relationship between Gasdermin-D levels in preterm labor | 12 months | the relationship between Gasdermin-D levels of patients diagnosed with preterm labor and spontaneous preterm labor in pregnant women. |
Countries
Turkey (Türkiye)
Outcome results
None listed