Cardiovascular Abnormalities, Steroid Abuse
Conditions
Brief summary
Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.
Interventions
DIETARY_SUPPLEMENTBeetroot juice rich in nitrate
The participant will intake beetroot juice rich in NO3 (800mg). Two hours after intake the last bottle of juice, the participants will go to the laboratory for the handgrip and cardiovascular tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols.
DIETARY_SUPPLEMENTBeetroot juice depleted in nitrate
The participant will intake beetroot juice depleted in NO3. Two hours after intake the last bottle of juice, the participants will go to the laboratory for the handgrip and cardiovascular tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols.
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Anabolic steroid use in the past or actually; * Participation at least one bodybuilding competition;
Exclusion criteria
* Previous history of acute myocardial infarction and/or stroke; * Allergy or intolerance to nitrate, gluten, or milk; * Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Values of systolic and diastolic blood pressure (mmHg) | up to 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Values of hand grip strength (kgF) | up to 2 years |
| Values of heart rate variability (ms) | up to 2 years |
| Macrovascular function (Flow mediated dilatation%) | up to 2 years |
| Values of heart rate (beats per minute) | up to 2 years |
| Plasmatic concentrations of nitrate and nitrite (mmol/L) | up to 2 years |
Countries
Brazil
Outcome results
None listed