Corneal Endothelium
Conditions
Brief summary
To determine what proportion of patients have inferior angle recess dimensions that could accommodate the OTX-TIC, and what are risk factors for implant contact with the corneal endothelium.
Interventions
OTHEROCT Imaging
Each participant will receive imaging of the inferior sectors of the iridocorneal angle at 150°, and 180°, and 210° with the swept-source ANTERION AS-OCT system under standardized light and dark lighting conditions by a trained research technician
Sponsors
University of Southern California
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age over 40 years * No history of ocular surgery other than cataract surgery
Exclusion criteria
\- Media opacities that preclude OCT imaging of the anterior segment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Primary Outcome 2 | 4-6 Months | Characterize the variability in distance (mean and standard deviation) between the angle recess and Schwalbe's line |
| Primary Outcome 1 | 4-6 Months | Predict contact between simulated OTX-TIC implant and corneal endothelium imaged using the ANTERION AS-OCT system. |
| Primary Outcome 3 | 4-6 Months | Calculate the proportion of eyes with predicted contact between the simulated implant and corneal endothelium. |
| Primary Outcome 4 | 4-6 Months | Develop logistic regression models to identify demographic, clinical, and biometric risk factors for predicted contact. |
Countries
United States
Outcome results
None listed