Association Between Fibrinogen-to-albumin Ratio and Delirium After Deep Brain Stimulation Surgery in Parkinson's Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05833308

Enrollment

226

Registered

2023-04-27

Start date

2021-01-01

Completion date

2023-01-31

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Brain Stimulation, Parkinson Disease, Postoperative Delirium

Keywords

postoperative delirium, fibrinogen-to-albumin ratio

Brief summary

Postoperative delirium (POD) remains one of the most common neuropsychiatric complications after deep brain stimulation (DBS) surgery. The fibrinogen-to-albumin ratio (FAR) has been shown to significantly correlate with prognosis of many diseases associated with inflammation, but the relationship between FAR and POD is unclear. The investigators aimed to investigate the association between POD and FAR in Parkinson's disease (PD) patients receiving DBS surgery. For this aim, the present study was conducted to provide a new method for the early recognition and perioperative management of delirium after DBS surgery in PD patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

Inclusion criteria

* Over 55 years old * American Society of Anesthesiologists (ASA) physical status I-III * Bilateral subthalamic nucleus deep brain stimulation surgery

Exclusion criteria

* Preoperative delirium * Missing preoperative laboratory parameters on fibrinogen or albumin * Persistent infectious diseases * Coagulopathy and autoimmune-illness or malignancies

Design outcomes

Primary

Measure	Time frame	Description
CAM score	Before surgery	Positive CAM score means that patient developed delirium after surgery. While negative CAM score means that patient did not suffer from delirium after surgery.

Secondary

Measure	Time frame	Description
The level of fibrinogen-to-albumin ratio (FAR) in peripheral blood.	Before surgery	The FAR was calculated as fibrinogen / albumin.
MMSE score	Postoperative 24 hour	MMSE score ranges from 0 to 30 and higher score means better cognitive function.
Mini-mental State Examination (MMSE) score	Before surgery	MMSE score ranges from 0 to 30 and higher score means better cognitive function.

Countries

China

Outcome results