Anemia Complicating Childbirth, Anemia Complicating Pregnancy, Anemia Complicating the Puerperium
Conditions
Keywords
Anemia
Brief summary
The goal of this observational and cross-sectional study is to develop and validate a survey that can be used to identify anemia, and its severity, among pre-pregnant women allowing for the timely implementation of focused public health and personalized interventions. Participants will be asked 26 survey questions about menstrual history and provide a 5 ml venous blood sample to measure hemoglobin, ferritin, and transferrin saturation levels.
Detailed description
Despite a variety of governmental campaigns and funded programs, anemia rates among reproductive age women in low- and middle-income countries (LMICs) have not decreased over the past few decades. Iron deficiency is associated with increases in morbidity and mortality in both non-pregnant and pregnant women, as well as their offspring. Up to 500 currently married women between 18 and 25 years old who are not pregnant, have never been pregnant, and are not using any type of contraception other than barrier methods will be recruited for this study from primary health centres (PHCs) in Belagavi , Karnataka, India. Accredited Social Health Activists (ASHAs) will identify potentially eligible participants and bring them to participating primary healthcare centers (PHCs) for screening, consent, and enrollment. Once enrolled, trained female interviewers will administer the PREPSA survey to the participant and a laboratory technician will draw a blood sample (upon completion of the survey or within four weeks) to analyze hemoglobin, ferritin, and transferrin saturation values. The survey responses that most closely align with low iron indices will be identified and become the basis of a scored, validated instrument which may be weighted based upon the strength of the associations found. Results will inform future health outcome trials.
Interventions
None listed
Sponsors
Global Network for Women's and Children's Health Research
Thomas Jefferson University
Jawaharlal Nehru Medical College
RTI International
NICHD Global Network for Women's and Children's Health
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 - 25 year old women * Not currently pregnant and have never been pregnant * Currently married * If last menstrual period \>6 weeks ago, exclude pregnancy via pregnancy test
Exclusion criteria
* Currently using any form of contraception other than barrier methods
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Validation of survey instrument | Up to four weeks following pre-pregnancy administration of PREPSA scale | The PREPSA Scale will be administered to pre-pregnant women and a blood draw within four weeks will be used to assess anemia status and support validation of the PREPSA Scale. The minimum value on the scale is a score of zero. The maximum value on the scale is a score of forty. This is based on the number of items plus the value of the highest coded category on items with more than one category. A higher score means a worse outcome and is associated with higher levels of iron deficient anemia. |
Countries
India
Outcome results
None listed