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Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection.

Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05831761
Enrollment
83
Registered
2023-04-26
Start date
2009-09-01
Completion date
2013-10-01
Last updated
2023-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

postoperative analgesia, neuropathic pain, laparoscopic colorectal surgery

Brief summary

Comparison of different postoperative analgesia after laparoscopic colorectal surgery

Detailed description

Postoperative pain treatment should be multimodal and opioid sparing. Thoracic epidural analgesia could relieve pain after laparoscopic surgery. Although ERAS guidelines suggest to use less invasive pain relieve technique, opioids are widely used perioperatively, despite of their side effects. Non-opioids and 5% lidocaine patches, used topicaly, could effectively reduce opioid consumption and their side effects. Namely, efficient perioperative pain treatment is important to prevent late neuropathic pain, also after laparoscopic lower abdominal surgery. Its incidence is usually low compared to open surgery. The aim of present study was to evaluate, if opioid consumption in laparoscopic colorectal surgery could be reduced with lidocaine patch at the wound site or with infusion of metamizole and tramadol and if the results meets epidural analgesia. We also compared the incidence of postoperative neuropathic pain among groups. Prospective, randomised trial with 4 parallel groups was conducted at the University medical centre (UMC) Ljubljana. ASA (American Society of Anaesthesiologists) Class 2-3 high risk surgical patients from the Clinical department of abdominal surgery were included in the study. Adult patients that underwent laparoscopic colorectal surgery were included.

Interventions

DRUGComparison of analgesic efficacy protocol

Comparison of 4 possible analgesic protocols

Sponsors

University Medical Centre Ljubljana
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Masking description

Randomised by random number generator after meeting the inclusion criteria.

Intervention model description

4 parallel groups with different method of analgesia after laparoscopic colorectal resection.

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* scheduled elective laparoscopic colorectal surgery

Exclusion criteria

* critical preoperative state, pregnant women, laparotomy and palliative procedures.

Design outcomes

Primary

MeasureTime frameDescription
Presence of neuropathic painfirst 3 months after surgeryDetecting of neuropathic pain using DN4 and PainDetect Questionnaire. These are clinically validated tools for detecting the presence of neuropathic pain and evaluating the severity.
Total opioid consumption0-48 hours after surgical procedureMeasurement of piritramide consumprion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026