Fluid Challenge Impact in the Portal Vein Pulsatility Depending on the Fluid Responsivness Status

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05828407

Acronym

FLUID-REVENGE

Enrollment

Registered

2023-04-25

Start date

2023-07-10

Completion date

2024-06-03

Last updated

2024-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Insufficiency, Venous Congestion

Keywords

Point of care ultrasound, Portal vein pulsatility index, Venous congestion, Preload dependence

Brief summary

Portal vein pulsatility index is a marker of venous congestion evaluated by point of care ultrasound. It is associated with acute kidney injury, especially in critically ill patients. It may be considered as a dynamic marker. The investigators hypothesized that portal vein pulsatility index is higher after a fluid challenge only in patient without preload dependence in critically ill patients with cardiovascular insufficiency.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* vasopressor requirement to maintain mean arterial pressure \>65mmHg AND * at least one of the following criteria: * arterial lactate \>2mmol/L; * capillary refill time \>3s; * mottling score \>1; * diuresis \<0,5mL/h for more than 6hours.

Exclusion criteria

* Diameter of vena cava \<20mm * Cirrhosis * Pregnancy * Severe acute pulmonary edema * Phototype 4 or 5 * Patient opposition to participate

Design outcomes

Primary

Measure	Time frame	Description
Portal vein pulsatility index variation induced by the fluid challenge (%), defined by: Portal vein pulsatility index before the fluid challenge - portal vein pulsatility index after the fluid challenge.	One hour	Portal vein pulsatility index is defined as the (maximal velocity - minimal velocity) / maximal velocity assessed with doppler in portal vein estimated with point of care ultrasound.

Countries

France

Outcome results