The Usefulness of Antibiotics in Smokers Receiving Dental Implants

Asepsis During Periodontal Surgery Involving Oral Implants and the Usefulness of Antibiotics: a Prospective, Randomized, Controlled Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05827211

Enrollment

Registered

2023-04-24

Start date

2023-04-02

Completion date

2023-06-10

Last updated

2023-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Implant Therapy

Brief summary

Objectives: This randomized clinical trial will compare the usefulness of pre- and postoperative antibiotics while strict asepsis will be followed during periodontal surgery in smokers diagnosed with Stage III Grade C Generalized Periodontitis. Material and Methods: Two groups of 40 consecutive patients each with fully or partially edentulous jaws will be enrolled. Antibiotics group (GrAB+): will receive oral doxycycline 200 mg, 1 h pre-operatively and 100 mg g for 9 days post-operatively. Non-antibiotics group (GrAB- ): will receive a placebo (no antibiotics). Bacterial samples will be taken from the peri-oral skin before and at the end of the surgery. In 12 patients in each group, samples will also be taken from the nares. A visual analogue scale will evaluate symptoms of infection/ inflammation by both the patient and the periodontist at suture removal.

Interventions

PROCEDUREAntibiotic group

Partially or fully edentulous smoker patients will be treated by dental implants and will receive systemic antibiotics

PROCEDURENon-Antibiotic group

Partially or fully edentulous smoker patients will be treated by dental implants and will receive placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* smoker * in need of dental implant therapy * above 18 years of age

Exclusion criteria

* allergy to doxycycline, * need for endocarditis prophylaxis, * any systemic or local immunodeficiency, * uncontrolled diabetes mellitus, * previous radiation therapy in the head and neck area

Design outcomes

Primary

Measure	Time frame	Description
Rate of post-operative infection	7 days	signs of infection (fever \> 38 degrees celsius, spontaneous bleeding, pus, swelling, etc.) post-operatively will be checked at suture removal

Countries

Palestinian Territories

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026