Fructose Metabolism Disorder
Conditions
Brief summary
Epidemiological evidence is accumulating that a high consumption of added sugars is associated with metabolic diseases such as non-alcoholic fatty liver disease and type 2 diabetes. Fructose, one of the principal added sugars, is believed to be the most disadvantageous sugar. Data from a large population-based cohort demonstrated that fructose intake from fruit juice and sugar-sweetened beverages, but not whole fruits, is associated with higher intrahepatic lipid content. A study in mice demonstrated that fast fructose exposure resulted in higher intrahepatic lipid content than slow fructose exposure. The food matrix, i.e. the complex spatial organisation of and interactions between nutrients, may account for the fast versus slow fructose exposure and subsequent health consequences. Therefore the investigators aim to investigate the role of the fructose matrices on serum fructose peaks. The investigators hypothesize that liquid fructose matrices will cause higher serum fructose peaks in comparison to solid fructose matrices. Objective: To quantify serum fructose peaks within 150 minutes following intake of fructose-containing matrices.
Interventions
OTHERApple
20g fructose in \[x\] g of apple
OTHERMashed apple
20g fructose in \[x\] g of mashed apple
OTHERApple juice
20g fructose in \[x\] ml apple juice
OTHERFructose powder in water
20g fructose in \[x\] ml water
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
This study is an open-label, randomized, single meal, cross-over study in healthy individuals.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 years. * Body mass index (BMI) ≥18.5 kg/m2 and \<25 kg/m2
Exclusion criteria
* Pregnancy. * Drugs and/or alcohol abuse. * Diagnosis of diabetes mellitus. * (History of) gastrointestinal and/or liver disease. * (History \[\< 5 years\] of) cancer (excluding basal cell carcinoma) * Physical stress one month prior to inclusion (i.e. post-surgery, trauma that requires medical treatment, bacterial/viral/fungal infection or extreme psychological stress). Symptoms of infection include: fever, (excessive) sweating & chills, cough, sore throat, shortness of breath, nasal congestion, diarrhea, vomiting, painful miction, redness/swelling, stomach ache, head ache, and stiff neck. * Unstable weight for 3 months prior to inclusion (i.e. 5% change in bodyweight) * Allergy to one of the used food products in the study. * Inability to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum fructose between peak and baseline | Time points 0, 15, 30, 45, 60, 75, 90, 105, 120, 135 and 150 minutes following consumption of the food product. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | Time points 0, 15, 30, 45, 60, 75, 90, 105, 120, 135 and 150 minutes following consumption of the food product. | Millimeter of mercury |
| Serum uric acid | Time points 0, 15, 30, 45, 60, 75, 90, 105, 120, 135 and 150 minutes following consumption of the food product. | Millimoles per liter |
Countries
Netherlands
Outcome results
None listed