Allergy;Food, Allergy, Nut
Conditions
Keywords
allergy, food allergy, cashew nut allergy, oral immunotherapy, pistachio allergy
Brief summary
The objectives of the CAJESITO study are (i) to assess the tolerance of oral cashew nut immunotherapy, by describing the frequency and severity of allergic reactions during oral cashew nut immunotherapy and (ii )to assess the risk factors for severe allergic reactions during oral cashew nut immunotherapy (predictive factors, associated factors.
Interventions
OTHERNo intervention
No intervention, it's an observational study
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients under the age of 18 with a proven allergy to cashew nuts and followed in the pediatric allergology unit of the University Hospital of Nancy. * Patients who have received oral cashew nut immunotherapy for at least 18 months as of 02/28/2023
Exclusion criteria
* Patients who have received oral cashew nut immunotherapy for less than 18 months. * Patients lost to follow-up for more than 3 years, i.e. last consultation dating from 2020 or earlier
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of allergic reaction | during 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Predictive factor of good tolerance | during 6 months | age at onset |
| antibody variation | during 6 months | Modification of level of specific IgE and IGg4 with cashew nuts |
| sustained unresponsiveness | 9 months | Tolerance of 1, 2, 4, 8g in isolated doses and 15g in total cumulative dose of cashew nuts during an oral challenge test with cashew nuts 3 months after stopping the daily consumption of 2g of cashew nuts |
| oral tolerance of pistachio | 6 months | Tolerance of 1, 2, 4, 8g in isolated doses and 15g in total cumulative dose of pistachio during an oral provocation test with pistachio 3 months after stopping the daily consumption of 2g of cashew nuts |
Contacts
Primary ContactAmandine AD DIVARET-CHAUVEAU, MCU PH
Outcome results
None listed