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Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life After Laparoscopic Sleeve Gastrectomy

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05826210
Enrollment
245
Registered
2023-04-24
Start date
2015-01-01
Completion date
2022-12-31
Last updated
2023-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body Composition, Sarcopenic Obesity

Keywords

laparoscopic sleeve gastrectomy, weight loss, sarcopenic obesity, Fat-free mass, Quality of life

Brief summary

The purpose of this study is to assess the impact of sarcopenic obesity (SO) on weight loss outcomes and improvement of quality of life after laparoscopic sleeve gastrectomy.

Detailed description

Sarcopenic obesity is a state in which a lack of muscle mass and strength coexists with an increase in fat mass, and it may affect the health outcome of people with obesity after laparoscopic sleeve gastrectomy (LSG).No studies have reported differences in weight loss outcomes between patients with SO and those with non-sarcopenic obesity (NSO) after LSG. Therefore, this study aimed to systematically evaluate the differences in weight loss and quality of life (QOL) evaluation between patients with SO and NSO after LSG and provide high-level evidence-based medical evidence for the impact of SO on weight loss in the obese population and refinement of follow-up strategies.

Interventions

PROCEDURELaparoscopic sleeve gastrectomy

Laparoscopic sleeve gastrectomy was performed in all patients with or without SO.

Sponsors

Fujian Medical University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Obese patients who met the indications for LSG and were followed up regularly as planned after surgery.

Exclusion criteria

1. incomplete critical clinical data; 2. incomplete imaging data; 3. insufficient follow-up data.

Design outcomes

Primary

MeasureTime frameDescription
%EWL6 month after surgeryPercentage excess weight loss is calculated as (initial weight - 6-month weight)/(initial weight - ideal weight) × 100%.

Secondary

MeasureTime frameDescription
%TWL6 month after surgeryPercentage total weight loss is calculated as (initial weight - 6-month weight)/(initial weight) × 100%
EBMI6 month after surgeryExcess BMI is calculated as(follow-up BMI - ideal BMI)
%EWL1 month after surgeryPercentage excess weight loss is calculated as (initial weight - 1-month weight)/(initial weight - ideal weight) × 100%.
MA II score6 month after surgeryMoorhead-Ardelt QOL questionnaire is a six-item self-report questionnaire that assesses the patient's subjective impression of QOL,The total score ranges from -3 to +3 and defines five outcome groups: very poor, poor, fair, good, and very good. Good and very good outcomes were considered satisfactory.
BAROS score6 month after surgeryThe Bariatric Analysis and Reporting Outcome System(BAROS)combines the Moorhead-Ardelt QOL questionnaire with other data relevant to bariatric surgery, including the %EWL, improvement in comorbid conditions, and complications.A BAROS score ≤1 was considered a failure; \>1-3, fair; \>3-5, good; \>5-7, very good; and \>7, excellent.
%WL6 month after surgeryPercentage weight loss is calculated as (follow-up weight/initial weight) × 100%

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026