Coronary Artery Disease
Conditions
Brief summary
The Purpose of this study is to better understand changes in obstructive coronary artery disease in different organs other than the heart such as the brain and the kidneys using a new generation total body PET scanner.
Detailed description
Patients with chest pain and suspected CAD will be studied using total body PET imaging with O15-water perfusion imaging
Interventions
None listed
Sponsors
Turku University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Documented history of chest pain with CT imaging showing a potential for obstructive coronary artery disease * Ability to sustain adenosine injection 0.14 mg/kg/min
Exclusion criteria
* Second or third degree AV-block without pacemaker * Sick sinus syndrome * Consumption of coffee or aminophylline within 12 hours of administration * Recent use of dipyridmole or dipyridamole-containing medications * Known hypersensitivity to adenosine * Unstable acute MI or acute coronary artery syndrome, and prior cardiac transplantation * Active wheezing and bronchospasm * Sinus bradycardia with HR\<40 bmp
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perfusion in heart, brain and kidneys during rest and adenosine stress, and their associations with psychologic factors and anginal symptoms | The imaging day | Multiorgan perfusion changes in patients with chest pain |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The association between perfusion in heart, brain and kidneys, and adverse events during five year follow-up | Five year follow-up after the imaging | Multiorgan perfusion changes in patients with chest pain as related to outcome |
Countries
Finland
Contacts
Primary ContactJuhani Knuuti, MD
Outcome results
None listed