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Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients

Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05825638
Enrollment
12
Registered
2023-04-24
Start date
2023-01-10
Completion date
2025-10-10
Last updated
2026-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Desaturation of Blood, Exercise, Pulmonary Rehabilitation

Keywords

COPD, Pulmonary rehabilitation, Interval training

Brief summary

A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients. The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.

Interventions

OTHERContinuous training session

Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power

OTHERInterval training session

Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.

Sponsors

Groupe Hospitalier du Havre
Lead SponsorOTHER
Medrinal Clement
CollaboratorUNKNOWN
Combret Yann
CollaboratorUNKNOWN
Machefert Margaux
CollaboratorUNKNOWN

Study design

Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* a diagnosis of COPD * participating in a pulmonary rehabilitation programme * with an exercise-induced desaturation less than 90% * no oxygen supplementation

Exclusion criteria

* Under 18 years of age * Pregnant woman * Person not affiliated to a health insurance regime or not benefiting from a social security regime * Patient under curatorship, guardianship or safeguard of justice * Patient speaking a language other than French * Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise * Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks * Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort * Breastfeeding women

Design outcomes

Primary

MeasureTime frameDescription
Difference in oxygen pulsed saturationOne weekDifference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)

Secondary

MeasureTime frameDescription
Difference in oxygen pulsed saturationOne weekDifference in mean pulsed oxygen saturation and the time spent with a pulsed oxygen saturation below 90% during the two training sessions. The measurement will be performed with a pulse oximeter (Spirodoc, MIR)
Difference in peripheral muscle oxygenationOne weekMuscle oxygenation (arbitrary unit) will be evaluated using Near-infrared spectroscopy technology. the measurement will be performed with a Near Infrared spectroscopy (Portamon, Artinis Medical Systems)
Difference in respiratory rateOne weekDifference in respiratory rate will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)
Difference in tidal volumeOne weekDifference in tidal volume will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)
Difference in inspiratory capacityOne weekDifference in inspiratory capacity will be measured using a portable spirometer (Spirodoc, MIR)
Difference in DyspneaOne weekDyspnea peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea
Difference in muscle discomfortOne weekMuscle discomfort peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea

Countries

France

Contacts

PRINCIPAL_INVESTIGATORGuillaume Prieur, PT, PhD

Groupe Hospitalier du Havre

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026