EPIRUS FH Reverse Cascade Screening

Reverse Cascade Screening for Familial Hypercholesterolemia in Children and Adolescents in Northwest Greece

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05825612

Enrollment

1000

Registered

2023-04-24

Start date

2023-05-31

Completion date

2033-05-31

Last updated

2023-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Familial Hypercholesterolemia

Keywords

children, adolescents, reverse cascade screening

Brief summary

Familial hypercholesterolemia (FH) is the most common inherited metabolic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C). If left untreated, lifelong exposure to elevated LDL-C leads to a substantially increased risk of premature cardiovascular disease as compared to the general population. Although FH adverse cardiovascular outcomes are potentially preventable through early identification of FH individuals and initiation of effective treatment, available evidence shows that FH is under-diagnosed and under-treated. Childhood is the optimal period for FH screening, because due to minimal dietary and hormonal influences, LDL-C levels reflect predominantly the genetic component in children and are well suited to discriminate FH from other causes of elevated LDL-C. If FH remains untreated in this latent stage of the disease, individuals show a 10-fold increase of cardiovascular risk during early and middle adulthood. In this context, an effective approach for detecting FH would be a screening during childhood or in young adolescents in combination with reverse cascade screening of first-degree relatives of FH individuals. EPIRUS-FH registry is a model program of reverse cascade screening for FH in children and adolescents in Northwest Greece that aims to increase public and physician awareness, strengthen the national registry of familial hypercholesterolemia (HELLAS-FH) and constitute the core for a national FH registry in children and adolescents in Greece.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

4 Years to 16 Years

Healthy volunteers

Yes

Inclusion criteria

* LDL-C \>160 mg/dL on two seperate measurements 3 months apart * LDL-C \>130 mg/dL + family history of premature coronary artery disease or hypercholesterolemia in one parent * Children and adolescents on cholesterol-lowering medication

Exclusion criteria

* Refusal to sign the consent form and disagreement with the terms of participation. * Any clinically significant disorder recognized at the time of the preliminary assessment, which in the judgment of the investigator would disqualify patient's participation in the study.

Design outcomes

Primary

Measure	Time frame	Description
Diagnosis of Familial Hypercholesterolemia	Baseline	Type of FH (Heterozygous FH, Homozygous FH). In the case of genetic diagnosis, what gene was affected (LDL receptor, Apolipoprotein B, PCSK9, LDLRAP1, other to be specified). Age at diagnosis of FH.

Contacts

Primary ContactHaralampos Milionis

hmilioni@uoi.gr+302651099736

Backup ContactFotios Barkas

f.barkas@uoi.gr+306936636376

Outcome results