Cerebral Ventricle, Cerebrospinal Fluid, Hydrocephalus, White Matter Fiber
Conditions
Keywords
Hydrocephalus, cerebral ventricles, cerebrospinal fluid, white matter fibers, functional biomarkers
Brief summary
Hydrocephalus is characterized by excessive accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. One of the forms of hydrocephalus is called normal pressure, although one of the main signs is precisely an alteration of the intracranial pressure (ICP), it is here called active hydrocephalus (HA). Although MRI is the reference radiological modality for the characterization of HA. The Evan's and DESH index are radiological diagnostic criteria based on the dilation and morphology of the CSF compartments. These morphological indices remain insensitive and specific. In recent years, advances in Phase Contrast (MRI-PC) and Diffusion (MRI-DTI) MRI have generated new biomarkers of brain viability. The aim of this study is to characterize by MRI the impact of hydrocephalus on brain fluids and tissues.
Interventions
OTHERMRI
During management, patients with hydrocephalus will be subjected to flow MRI and diffusion MRI. Flow parameters and diffusion parameters will be measured and compared to those found in control subjects receiving the same type of imaging
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* For Patients with hydrocephalus: * Age \> 55, * Ventricular dilation: Evans Index \> 0.3; * Patients with cognitive impairment, and gait disturbances and/or urinary incontinence or a combination of these three symptoms; * Absence of other neurological diseases that could cause ventriculomegaly, information and non-opposition. * For Controls: * Age ≥ 55; * No ventricular dilation: Evans Index \< 0.3; * Individuals who have no neurological or psychiatric disease; * No neurological deficit. * No history of neurosurgery or head trauma; * signed informed consent; * affiliation to a social security scheme.
Exclusion criteria
* All patients who have a neurological disease other than active hydrocephalus will be excluded; * Individuals unable to sign or understand consent; * Individuals with psychiatric, neurological or medical development; * Individuals under treatment with psychoactive drugs; * Individuals who cannot tolerate an MRI examination; * Any individual with implant, pacemaker, prosthesis and ferromagnetic object
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation of MRI flow between both groups | 3 years |
| Variation of MRI diffusion between both groups | 3 years |
Countries
France
Contacts
Primary ContactOlivier BALEDENT, MD
Outcome results
None listed