Consciousness Disorder
Conditions
Keywords
Prolonged Disorders of Consciousness, Propofol, Brain Functional connectivity, Electroencephalography
Brief summary
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials
Interventions
DRUGDifferent drug dosage
Choice of Anesthesia
Sponsors
Beijing Tiantan Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 - 65 years old, native Chinese speaker, dextromanuality; * Chronic disorder of consciousness; * Spinal cord electrical stimulator implantation under general anesthesia; * Signed informed consent.
Exclusion criteria
* Continuous sedation was administered within 72 hours prior to the study; * Open head injury, parenchymatectomy and other damage of brain structural integrity; * The intracranial compliance decreased due to hydrocephalus and swelling; * Known hearing impairment; * Airway stenosis and various causes of severe ventilation or ventilation dysfunction; * Known or suspected cardiac dysfunction; * Allergic to intravenous general anesthetics; * Associated with other mental or neurological diseases; * Other reasons are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG Spectral Characteristics | During the trial(up to 3 hours for each subject) | Characteristics of EEG power spectrum(for 1-30 Hz) in patients with chronic consciousness disorder under different doses of drugs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cortical Connectivity | During the trial(up to 3 hours for each subject) | Characteristics of the weighted phase lag index in patients with chronic consciousness |
| Derived quantitative indicators | During the trial(up to 3 hours for each subject) | Characteristics of EEG derived quantitative indicators with chronic consciousness disorder during anesthesia recovery |
| Characteristics of sleep | During the trial(up to 24 hours for each subject) | Characteristics of sleep cycle in patients with chronic disorders of consciousness |
| Dynamic Patterns of Cortical Connectivity | During the trial(up to 3 hours for each subject) | The time-frequency characteristics of the weighted phase lag index in patients with chronic disorders of consciousness |
| Rate of patients recovered consciousness after surgery | During the trial(through study completion, 180 days) | Rate of patients recovered consciousness 30 days, 90 days, 180 days after surgery |
Countries
China
Outcome results
None listed