Fertility Disorders, Gynecologic Cancer
Conditions
Keywords
fertility sparing, gynecologic malignancy, quality of life, infertility
Brief summary
FSS which aims to preserve a woman's fertility while still effectively treating the cancer, has become an increasingly popular option for young women diagnosed with these types of cancers. It is important to assess how FSS affects a woman's reproductive health, sexual function, psychological well-being, and overall quality of life. This research aims to provide valuable insights into the long-term effects of FSS on a woman's life, and can help healthcare providers make informed decisions about the best treatment options for their patients.
Detailed description
This is a prospective cohort study that aims to evaluate the infertility and pregnancy outcomes, as well as the quality of life of women who underwent fertility-sparing surgery for gynecological malignancies. The study included a comprehensive evaluation of the participants' medical history, surgical procedures, oncological treatment, and fertility preservation methods. Participants recruited from a tertiary care hospital, and women diagnosed with gynecological malignancies (e.g. cervical, ovarian, endometrial cancer) who underwent fertility-sparing surgery between 2010 and 2022. Women who have undergone total hysterectomy, bilateral salpingo-oophorectomy, or adjuvant oncological treatment were excluded from the study. Participants were contacted by phone and asked to complete questionnaires to assess their quality of life using the WHOQoL-BREF and FertiQoL scales.
Interventions
PROCEDUREFertility sparing surgery
Sparing the uterus and/or ovaries of the patients suffering from gynecologic malignancies to keep the patients' fertility
Sponsors
Acibadem University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
The study included a comprehensive evaluation of the participants' medical history, surgical procedures, oncological treatment, and fertility preservation methods.
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 49 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of gynecologic cancer, and being fertile in the meantime * Applying directly to gynecologic oncology department * Demand of preserving the fertility
Exclusion criteria
* Having hysterectomy prior to the diagnosis * Having bilateral ooferectomy prior to the diagnosis * Being in menopause * Not accepting to fill the survey * High stage disease which is not able to have FSS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of pregnancy of patients received FSS | In 12 years after FSS | Incidence and rate of patients getting pregnant after FSS |
| Rate of pregnancy after FSS of patients seeking fertility by applying to IVF clinics | In 12 years after FSS | Rate of patients referring to IVF clinic after FSS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Satisfaction assesed by WHO-QoL Bref and decision-regret scale after FSS | 12 years | % of patients' satisfaction via Quality of life after the surgery, and decision-regret analysis regarding to fertility sparing by the validated questionnaires |
Countries
Turkey (Türkiye)
Contacts
Primary ContactNAZLI ALBAYRAK, MD
Outcome results
None listed