Atrial Fibrillation, Stroke, TIA
Conditions
Brief summary
The present study is an investigator-initiated, single-center, retrospective study based on data from the London Ontario Stroke Registry (LOSR), aiming to compare the characteristics and outcomes of ECG-detected and Device-Detected atrial fibrillation in patients with ischemic stroke and transient ischemic attack.
Detailed description
Patients with ischemic stroke and transient ischemic attack (TIA) without known atrial fibrillation (AF) are investigated with Prolonged Cardiac Monitoring (PCM) to detect AF. It is unclear if AF detected on 12-lead ECG after stroke occurrence bears the same risk of stroke as Device-detected AF. The investigators hypothesize, that Device-detected AF has a lower risk of ischemic stroke recurrence. The investigators will conduct a retrospective analysis of prospectively collected data from consecutive patients enrolled in the London Ontario Stroke Registry, (Ontario, Canada). The primary outcome will be a recurrent ischemic stroke at the end of the available follow-up window. The investigators will include ischemic stroke and TIA patients with ECG-detected AF and those with Device-detected AF on at least 7 days of Holter monitoring.
Interventions
DIAGNOSTIC_TESTProlonged cardiac monitoring
Prolonged cardiac monitoring
DIAGNOSTIC_TESTECG
Electrocardiogram
Sponsors
Luciano A. Sposato
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years * Patient with a diagnosis of ischemic stroke or TIA. * ECG-diagnosed AF or PCM-detected AF post ischemic stroke or TIA
Exclusion criteria
* Individuals younger than18 years-old * Patients without IS or TIA diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Recurrent Ischemic Stroke at End of available Follow-up Time | Duration of follow-up - minimum of 3 months after the first encounter with the stroke team | Documented recurrent ischemic stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Death | Duration of follow-up - minimum of 3 months after the first encounter with the stroke team | Number of patients dead at the end of the available follow-up |
| Readmission for decompensated AF or heart failure | Duration of follow-up - minimum of 3 months after the first encounter with the stroke team | Prevalence of readmission for decompensated AF or heart failure (HF) in each group |
| Prevalence of risk factors, cardiovascular comorbidities, and structural heart disease | Documented at baseline. | Proportion with vascular risk factors, cardiovascular comorbidities, and structural heart disease in each group |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORLuciano Sposato, MD, MBA (PI)
London Health Sciences Centre, Western University (London, ON. Canada)
Outcome results
None listed