Healthy Controls Without Orthostatic Hypotension
Conditions
Keywords
cognition
Brief summary
Background: In recent years, the changes of cognitive function in mild cognitive impairment have attracted attention. Methods/design: We will follow up at 3. The primary outcome will be the measurement of cognitive function using neuropsychological assessment scales such as MOCA, MMSE, etc... Minor variables will be included plasma biomarkers (Aβ, Tau, GFAP, etc.), multimodal brain electrophysiology (P300, VP300, heart rate variability, etc.), and neuroimaging indicators (NODDI).
Interventions
OTHERobservational study
observational study
Sponsors
Fujian Medical University Union Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Clinically diagnosed mild cognitive impairment
Exclusion criteria
* Patients with orthostatic hypotension * Patients with other neurological disorders. * Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Montreal Cognitive Assessment (MoCA) scores after 3 months. | Participants will be followed up for 3 months after baseline. | The MOCA scale scores range from 0 to 30, with higher scores indicating better cognition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Plasma amyloid protein levels after 3 months. | Participants will be followed up for 3 months after baseline. | Plasma amyloid protein(ug/ml) is an important indicator of cognitive function. |
| Changes in Plasma tau levels after 3 months. | Participants will be followed up for 3 months after baseline. | Plasma tau(ug/ml) is an important indicator of cognitive function |
| Changes in Blood pressure (mmHg) after 3 months. | Participants will be followed up for 3 months after baseline. | An experienced physician will measure blood pressure on the right upper arm after the subject rest for 5 min, taking the average of the two measurements as the final result. |
Countries
China
Contacts
Primary ContactXiaodong Pan, Doctor
Outcome results
None listed