Oral Squamous Cell Carcinoma
Conditions
Keywords
Oral squamous cell carcinoma, oral potentially malignant disorders, saliva, LINC00657, miR-106a.
Brief summary
This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included.
Detailed description
This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included, subdivided into 3 groups: Group I: 12 patients diagnosed with OSCC. Group II: 12 patients diagnosed with OLP. Group III: 12 systemically free individuals with no oral mucosal lesions. statistical analysis and ROC analysis were performed
Interventions
None listed
Sponsors
Fayoum University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* group I : oral squamous cell carcinoma lesions (OSCC) * group II: oral lichen planus lesions (OLP) * group III: systemically healthy volunteers
Exclusion criteria
* oral lesions other than OSCC / OLP in group I and II * any oral lesion in group III * pregnant females
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| LINC00657 level in salivary samples from all participants measured using PCR | level of miR-106a is measured after the completion of all salivary sample collection carried at the 1 day of enrollment of subjects in the investigation after diagnosis confirmation | quantitative real-time PCR is used to detect LINC00657 levels in saliva samples from patients with OSCC and OPMD compared to healthy subjects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| miR-106a level in salivary samples from the included subjects evaluated by PCR | level of miR-106a is measured after the completion of all salivary sample collection carried at the 1 day of enrollment of subjects in the investigation | quantitative real-time PCR is used to detect miR106a levels in saliva samples from patients with OSCC and OPMD compared to healthy subjects |
Countries
Egypt
Outcome results
None listed