Anemia, Hypoxia
Conditions
Brief summary
DDA is a new Doppler parameter aiming to assess fetal well-being in-utero. Early-onset SGR is a specific subgroup of fetuses where the clinical application of this Doppler modality could play an important role in the detection of hypoxia, anemia, and brain-sparing.
Interventions
DIAGNOSTIC_TESTDDA Doppler
A new Doppler parameter to quantify the amount of vasodilatation in the middle cerebral artery (MCA) and other blood vessels.
Sponsors
Orthogyn Medical Center, Bulgaria
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 48 Years
Inclusion criteria
* absence of fetal abnormalities and/or genetic conditions; * single pregnancy; * fetal growth restriction (FGR) \< 10%, according to the INTERGROWTH 21st nomograms, appearing before 32nd week of gestation
Exclusion criteria
* documented fetal abnormalities and/or genetic conditions in the course of the pregnancy; * multiple pregnancy; * absence of fetal growth restriction (FGR) \< 10%, according to the INTERGROWTH 21st nomograms before 32nd week of gestation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypoxia in the newborn | immediately after delivery | Defined by pH values below 7.20 in the umbilical artery |
| Anemia in the newborn | immediately after delivery | Hemoglobin deviation from GA mean - mild \< 20 g/L, moderate - 20-70 g/L, severe \> 70 g/L |
| Occurence of hypoxic-ischemic encephalopathy | first 72 hours after delivery | Occurence of hypoxic-ischemic encephalopathy in relation to some of the outcome measures |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Apgar score at 1st minute | 1 minute after delivery | Apgar score measured at 1st minute after delivery. Scores ranging from 1 to 10, with higher scores meaning a better outcome. |
| Admissions to a NICU | first 72 hours after delivery | Admissions to a NICU indicated by or related to some of the outcome measures |
| Apgar score at 5th minute | 5 minutes after delivery | Apgar score measured at 5th minute after delivery. Scores ranging from 1 to 10, with higher scores meaning a better outcome. |
| Apgar score at 10th minute | 10 minutes after delivery | Apgar score measured at 10th minute after delivery. Scores ranging from 1 to 10, with higher scores meaning a better outcome. |
Countries
Bulgaria
Contacts
Primary ContactPetar N Ignatov, PhD
Backup ContactTeodora B Yordanova-Ignatova, PhD
Outcome results
None listed