Motor Activity, Physical Inactivity, Postmenopausal; Menorrhagia
Conditions
Brief summary
Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 15 physically inactive hypertensive women will participate a 8-day trial, each with two intervention protocols: 1) placebo and 2) beetroot; in which will ingest beet juice with or without NO3 in its composition with a 8-day washout interval.
Interventions
DIETARY_SUPPLEMENTBeetroot juice rich in nitrate
The participant will intake beetroot juice rich in NO3 (400mg) during 8-days. On the eighth day of the intervention, 2 hours after intake the last bottle of juice, the participants will return to the laboratory for the performance tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols.
OTHERBeetroot juice NO3 depleted
The participant will intake beetroot juice depleted in NO3. On the eighth day of the intervention, 2 hours after intake the last bottle of juice, the participants will to the laboratory for the performance tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols.
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* 50 to 65 years old * Physically inactive * Postmenopausal diagnosis (amenorrhea for 12 months or more);
Exclusion criteria
* Smoking * Cardiac failure * Previous history of acute myocardial infarction and/or stroke; * Allergy or intolerance to nitrate, gluten, or milk;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Handgrip strength test (kgf) | up to 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Six minute walk test (distance in meters) | up to 2 years |
| Arm curl test (repetitions) | up to 2 years |
| Sit-to-stand test (repetitions) | up to 2 years |
| 8-foot up and go test (seconds) | up to 2 years |
Countries
Brazil
Outcome results
None listed