Sonography-Guided Volumetric Rejuvenation on Dorsal Hands

Sonography-Guided Volumetric Rejuvenation on Dorsal Hands: A Split-Hand Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05819450

Enrollment

200

Registered

2023-04-19

Start date

2023-04-15

Completion date

2024-12-31

Last updated

2023-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injection Site, Ultrasound

Keywords

Cosmetic, Volumetric rejuvenation, Filler, Dorsal hand, Ultrasound

Brief summary

The goal of this randomized controlled study is to guide volumetric rejuvenation on dorsal hands with the maximal aesthetic appearance. The main questions it aims to answer are: * Which fatty layer(s) is/are the most suitable for filler injection? * Is it feasible to make precise filler injections with sonography guidance? Participants will receive sonography-guided injection on the one hand and another with blinded injection.

Detailed description

In our previous study, volumetric fat loss was noted in the 3 fatty laminae of dorsal hands during aging; the dorsal intermediate lamina (DIL) showed the greatest progressive fat loss after the age of 30. Volumetric rejuvenation of the 3 laminae may result in the most aesthetic appearance, especially in women. It is necessary to develop precise rejuvenation therapies according to the aging process of the dorsum of the hands that will yield the most aesthetic appearance.

Interventions

PROCEDUREVolumetric rejuvenation

Volumetric Rejuvenation with FDA-approved fillers on the skin of the dorsal hands

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Diagnosis of aging changes on the dorsal hands * Aged ≥18 years

Exclusion criteria

* History of severe hand dermatitis * History of rheumatic arthritis * History of major hand trauma * History of limb edema * History of recent significant weight changes * History of previous filler injection to the dorsal hands * History of intravenous catheter insertion and hemodialysis via the forearms or hands

Design outcomes

Primary

Measure	Time frame	Description
Aesthetic improvement	Day 0, 30, 180 follow up	5-point global aesthetic improvement scales scoring (Min:1; Max:5)

Secondary

Measure	Time frame	Description
Thickness of the fatty laer	Day 0, 30, 180 follow up	Thickness of the dorsal superficial lamina (DSL) and dorsal intermediate lamina (DIL)

Countries

Spain, Taiwan

Contacts

Primary ContactYi-Teng Hung, MD

herovincent25@hotmail.com.tw+886972392650

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026