Retinal Disease
Conditions
Brief summary
To investigate the feasibility of a combined OCT/FLIM device
Detailed description
To investigate the feasibility of a combined Optical coherence tomography/ Fluorescence Lifetime Measurement (OCT/FLIM) device.
Interventions
DEVICEOCT/FLIM
OCT/FLIM imaging of the retina
Sponsors
Haag-Streit AG
University of Bern
Insel Gruppe AG, University Hospital Bern
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 120 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject must be willing to give written informed consent * Age: Patients and Probands 18 years or greater * Both eyes will be assessed in the study
Exclusion criteria
* Patients not willing or able to sign informed consent * Patients younger than 18 years * Patients with epilepsy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of device | 1 year | We will organize and perform an observational study with the prototype OCT+FLIM device and contribute the acquired OCT/FLIM datasets from eyes of different age and status of the crystalline lens. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To provide two key technology aspects of the project: | 1 year | A. The first will be to bring forward a novel registration strategy for calibrated OCT and FLIM modalities, so that these can be used in conjunction. B. The second will be to develop an image calibration and normalization method using the measured lens fluorescence lifetime and possibly also structural (OCT) information on lens and retina, so that data acquired by the device can be used across different patients in a consistent way. |
Countries
Switzerland
Contacts
Primary ContactPia Steinger
Outcome results
None listed