Chronic Kidney Diseases, Periapical Lesions
Conditions
Keywords
Apical Periodontitis, Root Canal Treatment
Brief summary
This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.
Detailed description
105 CKD patients (35 early (EG), 35pre-dialysis (PDG) and 35 hemodialysis (HDG)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . Inflammatory (hsCRP and ferritin) and nutritional (urea and creatinine) markers were estimated and eGFR was calculated for the study population. Logistic regression was used to determine the possible association between CKD and AP in study population and Linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (EB) in experimental group.
Interventions
BIOLOGICALlevels of CKD markers, Oral health status, apical periodontitis
To observe levels of CKD markers :Levels of serum keratinise ,urea, eGFR, and assessment of Oral health status, apical periodontitis
BIOLOGICALsystemic inflammatory marker, Oral health status, apical periodontitis
estimation of hs-CRP levels, and assessment of Oral health status, apical periodontitis
Sponsors
Postgraduate Institute of Dental Sciences Rohtak
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Known patient of CKD Stages 1,2,3,4 & 5 with estimated glomerular filtration rate \[eGFR; MDRD\] with mature permanent teeth. * \> 18 years * \> 8 natural teeth. * Complete medical & dental history including panoramic radiographs of maxilla & mandible
Exclusion criteria
* Patients having systemic disorders other than CKD (eg HIV, Diabetes mellitus, Coronary heart disease, history of secondary hyperparathyroidism). * Pregnancy, lactation & contraceptives. * Systemic conditions that contra indicates dental treatment. * Use of antibiotics & anti-inflammatory in last 3 months * Need for antibiotic prophylaxis. * Hepatitis C and B virus. * Patients on steroids.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Periapical Index(PAI) | 1 year | Periodical status will be assessed in periodical radiograph and scoring of periapical index will be done according to size and periphery of peri-apical radiolucency with coding 1 to 5 |
| eGFR | 1 year | BY BLOOD SAMPLE measured in mL/min/1.73m2 |
| serum creatinine | 1 year | BY BLOOD SAMPLE measured in mg/dL |
| hs-CRP | 1 year | HIGH SENSITIVE C-reactive protein measured by ELISA kit in mg/L |
| Blood urea | 1 year | measured by collecting blood sample in mg/dL |
Countries
India
Outcome results
None listed