Oral Mucositis
Conditions
Keywords
mucositis, hyaluronic acid
Brief summary
Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim of this study was to investigate the effect of hyaluronic acid (HA) gel on OM in children receiving CT.
Interventions
DRUGHyaluronic acid
The main function of HA appears to be in tissue healing, by activating and modulating inflammatory responses, stimulating cellular proliferation, migration, and angiogenesis, inducing basal keratinocyte proliferation and re-epithelization by reducing collagen deposition and scarring
DRUGSodium bicarbonate
sodium bicarbonate solution
Sponsors
Yuzuncu Yil University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* children who receive chemotherapy * hospitalized patient
Exclusion criteria
\- Allergy about using drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| World Health Organization Common Toxicity Criteria Scale | day 1st | The lesions were classified as Grade 0 = absent; Grade 1 = pain and erythema; Grade 2 = erythema and ulcers with no difficulty in swallowing solid food; Grade 3 = ulcers requiring only liquid diet; and Grade 4 = requiring parenteral and enteral nutrition support. |
| VAS pain score | Day 1st | A Visual Analogue Scale (VAS) is one of the pain rating scales between 1-10. |
Countries
Turkey (Türkiye)
Outcome results
None listed