Bradycardia
Conditions
Keywords
Leadless pacing, Synchronization
Brief summary
Comparison of cardiac synchronization and tricuspid regurgitation with or without leadless pacemaker pacing in different site
Detailed description
Right ventricular pacing might lead to pacing-induced cardiomyopathy by dyssynchrony and tricuspid regurgitation. Pacing at various sites had different effects on synchrony and tricuspid regurgitation. This study is to observe the effect of leadless pacemaker implantation in different regions on ventricular synchronization and tricuspid regurgitation. Ultrasound and ECG parameter indices are applied.
Interventions
DEVICELeadless pacemaker
To observe the effect of pacemaker implantation at different sites on cardiac synchronization and tricuspid regurgitation
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
First People's Hospital of Hangzhou
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
patients consent to LP implantation surgery
Exclusion criteria
1. Patients with inferior vena cava thrombus, a cancer thrombus, an abnormal inferior vena cava; 2. Patients with femoral vein stenosis and tortuosity failed to accommodate the pacemaker delivery system; 3. Patients with myocardial infarction; 4. Patients who have been implanted with devices that affect the pacemaker delivery system, such as vena cava filters or tricuspid valve mechanical valves; 5. cannot understand or are unwilling to give informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The evaluation of cardiac electrical synchrony | 1 month | the QRS duration after pacing |
| The evaluation of cardiac mechanical synchrony | 1 month | ①Synchronization analysis between left and right ventricles: interventricular mechanical delay (IVMD) in millisecond. ②Left ventricle synchrony analysis: septal-to-posterior wall motion delay (SPWMD) in millisecond，left pre-ejection interval(LPEI) in millisecond. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure may affect synchronization | 1 month | Systolic and diastolic blood pressure in mmHg |
| The pacemaker sensing may affect synchronization | 1 month | pacemaker sensing in millivolt |
| BMI may affect synchronization | 1 month | BMI in kg/m\^2 |
| Age may affect synchronization | 1 month | Age in years |
| The pacemaker lead impedance may affect synchronization | 1 month | lead impedance in ohm |
Countries
China
Contacts
Primary ContactYi zhou XU
Outcome results
None listed