BMAC Loaded Collagen Jumping the Gap Around Immediate Implants

Assessment of Collagen Loaded With Bone Marrow Aspirate Concentrate Versus Autograft on Marginal Bone Changes Around Immediate Implants in Esthetic Zone. A Randomized Controlled Clinical Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05817526

Enrollment

Registered

2023-04-18

Start date

2023-01-25

Completion date

2024-12-31

Last updated

2024-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Implantation, Implant Site Reaction

Brief summary

The present study aims to evaluate the effect of utilization of BMAC/ collagen on marginal bone changes around immediate implants in the esthetic zone of maxilla. Methodology: Twenty dental implants will be installed in the esthetic zone and patients will be randomly divided into two groups: study group: The jumping gap surrounding the immediate implants will be grafted with BMAC/collagen, whereas in the control group, autograft from the chin will be used to fill the defect. Cone beam CT (CBCT) will be requested Preoperative, immediate and 4 months Postoperative for assessment of marginal bone changes around implants. .

Detailed description

The aim of present study is to evaluate the effect of utilization of bone marrow aspirate concentrate (BMAC) loaded on collagen on the marginal bone changes around immediate implants in the esthetic zone of maxilla. Methodology: Twenty dental implants will be installed in patients suffering from non- restorable teeth in esthetic zone. Patients will be randomly divided into two equal groups: study group: The jumping gap surrounding the immediate implants will be grafted with bone marrow aspirate concentrate loaded on collagen, whereas in the control group, autogenous bone graft from the chin will be used to fill the peri-implant defect. CBCT will be requested Preoperative, immediate and 4 months Postoperative for assessment of marginal bone changes around dental implants. .

Interventions

DRUGBMAC/ collagen

Bone marrow aspirate concentrate loaded on collagen in the peri-implant defect

PROCEDUREAutograft harvesting from chin

Autograft

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with non- restorable teeth in esthetic zone * Patients above 18 us * Highly motivated patients.

Exclusion criteria

* patients with systemic diseases • immunocompromised patients . Patients with bleeding disorders

Design outcomes

Primary

Measure	Time frame	Description
Marginal bone changes	4 months	Buccal bone height

Countries

Egypt

Contacts

Primary ContactWalaa Kadry

walaakadry@dentistry.cu.edu.eg+201061527359

Backup ContactAhmed Amin

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026