Melanoma, Surgery
Conditions
Keywords
Melanoma, Surgery, Neutrophil-to-lymphocyte ratio, Surgical inflammation
Brief summary
We want to test if an association between sentinel lymph node biopsy (SLBN) and a systemic inflammatory response can be made.
Detailed description
Sentinel lymph node biopsy (SLBN) is essential in staging melanoma and properly selecting patients for adjuvant immunotherapy. However, surgically induced inflammation can potentially aid in progression of remaining malignant cells and affect prognosis. The inflammatory marker neutrophil-to-lymphocyte ratio (NLR) is also a negative prognostic and predictive marker in serval malignancies, among melanoma. However, it is not yet established if SLNB induces a systemic inflammatory response.
Interventions
PROCEDUREBlood samples
Blood samples
Sponsors
Aarhus University Hospital
Aalborg University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult (\>18 years of age) * Diagnosed with invasive cutaneous melanoma * Eligible for SLNB (Melanoma stage ≥ T1b) * Obtained signed informed consent
Exclusion criteria
* Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neutrophil-to-lymphocyte ratio | 1 Day | Ratio between neutrophil granulocytes and lymphocytes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pro-inflammatory cytokines | 1 Day | IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α, and IFN-γ |
| Acute phase reactants | 1 Day | CRP, LDH |
Countries
Denmark
Outcome results
None listed