Lung Perfusion
Conditions
Brief summary
The purpose of this research study is to see if a special CT scan (dual-energy CT) provides useful information in patients undergoing bronchsoscopic lung volume reduction (valve placement for emphysema). The investigators will enroll up to 30 participants in this study from University Hospitals Cleveland Medical Center. All of the participants from this study will undergo their valve procedure at University Hospitals Cleveland Medical Center.
Interventions
PROCEDUREDual Energy CT
Patient will receive Dual Energy CT
Sponsors
Sameer Avasarala
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (≥ 18 years of age at the time of written informed consent) with emphysema who have been deemed appropriate candidates for bronchoscopic lung volume reduction
Exclusion criteria
* Patients unable to provide consent * Patients who are pregnant or nursing * Women of child-bearing age will undergo pregnancy tests based on University Hospital (UH) standard bronchoscopy pre-procedural testing * Patients unable to undergo a DECT chest (contraindications to a CT chest with intravenous contrast such as a reported or documented allergy to intravenous (IV) contrast or impaired renal function, defined as the following: * Glomerular filtration rate (GFR) \<90 ml/min/1.73 m2 at the time of initial evaluation if patient age is ≤ 59 years * GFR \<85 ml/min/1.73 m2 if patient age is 60-69 years * GFR \<75 ml/min/1.73 m2 if patient age is ≥70 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in lung perfusion as measured by duel-energy computed tomography | Baseline, 8 weeks |
| Change in walk distance as measured by six-minute walk test | Baseline, 8 weeks |
| Change in FEV1 as measured by pulmonary function test | Baseline, 8 weeks |
Countries
United States
Outcome results
None listed