Clinical and Magnetic Resonance Imaging Evaluation of Micro Fragmented Adipose Tissue Injection Combined With Bone Marrow Stem Cells on Healing of Temporomandibular Joint Internal Disc Derangement Without Reduction

Clinical and Magnetic Resonance Imaging Evaluation of Micro Fragmented Adipose Tissue Injection Combined With Bone Marrow Stem Cells on Healing of Temporomandibular Joint Internal Disc Derangement Without Reduction (Randomized Control Pilot Clinical Trial)

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05815771

Enrollment

Registered

2023-04-18

Start date

2023-07-01

Completion date

2025-07-01

Last updated

2023-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular Joint Disorders

Brief summary

Arthrocentesis of TMJ then injection of micro fragmented adipose tissue mixed with bone marrow aspirate on healing of TMJ internal disc derangement without reduction.

Detailed description

Arthrocentesis of TMJ then injection of intra and periarticular of 2 mm of micro fragmented adipose tissue mixed with Bone marrow aspirate extracted from 20 mm of bone marrow using gradient separation method in one group and use of Bone marrow aspirate injection only in another group and injection of intra and periarticular of 2 mm hyaluronic acid gel in control group on healing of TMJ internal disc derangement without reduction.

Interventions

PROCEDUREMicro fragmented adipose tissue mixed with bone marrow stem cells

mixture of stem cells

PROCEDUREBone Marrow stem cells aspirate

stem cells

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients with TMDs not previously surgically treated. * Patients with TMJ osteoarthritis assessed by clinical examination and magnetic resonance imaging.

Exclusion criteria

* Patients refuse to be enrolled in this study. * Patients with uncontrolled systemic disease.

Design outcomes

Primary

Measure	Time frame	Description
Mandibular mouth opening	6 Months	Measuring Maximum interincisal opening measured by plastic scale ruler in millimeter

Secondary

Measure	Time frame	Description
Post-operative pain	six months follow-up	measuring pain by using visual analogue scale from (0 to 10) score where zero indicate no pain and 10 indicate worst pain
Joint sound	six months follow-up	Clicking by clinical examination indicate ( present or absent ) of clicking
Lateral and protrusive movements	six months follow-up	Measuring lateral and protrusive movements by using range of motion scale in millimeter

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026