Adverse Events, Body Composition, Haematology, Immunology, Inflammation, Plasmapheresis, Sport Performance
Conditions
Brief summary
Only very few studies have prospectively looked at the effect of repeated intensive plasma donation. In collaboration with the Rode Kruis Vlaanderen, we have recently found that repeated whole blood donation with a 3-month interval in between induced a drop in markers for iron status, which worsened with the number of donations. The repetition effect of the donations, whether whole blood or plasma, can be different from the effects measured after one single donation. It is therefore critical to test and document this repetitive effect to build trustable and valid guidelines concerning repetitive plasma donation.
Interventions
DEVICEPlasmapheresis
Plasma donation at different frequencies
Sponsors
Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* male, * age between 18-50 years * BMI between 20-28 kg/m2 * aptitude to perform maximal physical efforts assessed by the physical activity readiness questionnaire (PAR-Q)
Exclusion criteria
* The specific
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood markers | 3 months | albumin in g/l |
| Sport performance | 3 months | VO2max in mlO2/kg/min determined breath-by-breath on a cycloergometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | 3 months | fat mass in kg measured by DEXA |
| Blood pressure | 3 months | systolic and diastolic blood pressure in mmHG |
Other
| Measure | Time frame | Description |
|---|---|---|
| Blood markers | 3 months | red blood cells in 10\^6/mm\^3 |
| Weight | 3 months | in kg |
Countries
Belgium
Outcome results
None listed