Arterial Stiffness, Sodium Intake
Conditions
Brief summary
The purpose of this study is to explore the influence of sodium intake on arterial stiffness in African American/Black adults.
Interventions
BEHAVIORALLow-sodium intake
Participants will consume less than or equal to 720 milligrams of sodium per day for 3 days.
DIETARY_SUPPLEMENTHigh-sodium intake
Participants will supplement their existing diets with 10 salt tablets daily for 3 days.
Sponsors
Texas State University
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* African American or Black * Male or Female
Exclusion criteria
* pregnancy or within 60 days postpartum * having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months * infection (viral or other) within the past 4 weeks * having adrenal or endocrine tumors (these could impact BP) * renal disease defined as a glomerular filtration rate (GFR) of less than 60 * prior myocardial infarction * known coronary heart disease * personal history of stroke * heart failure * cardiac arrhythmias * recent chest pain or dyspnea * current insulin dependence * currently undergoing chemotherapy or radiation * identifying as transgender (the focus of this trial is biological sex) * seated systolic or diastolic blood pressure of more than 149 mm Hg or 99 mm Hg, respectively
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardio-ankle vascular index | This measurement will take approximately 1 minute and will be completed twice. | Cardio-ankle vascular index will be assessed using simultaneous arm and ankle blood pressures, EKG, and phonocardiography |
| Ambulatory blood pressure | This measurement will take approximately 24 hours and will be obtained from the date of enrollment until the date of completion of the study up to 10 days after enrollment. | 24-hour ambulatory blood pressure monitoring will be completed on day 3 of each dietary condition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Renal sodium excretion | This measurement will be obtained from the date of enrollment until the date of completion of the study up to 10 days after enrollment. | 24-hour urine samples will be analyzed for sodium concentrations and sodium excretion will be determined. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Hematocrit | This measurement will be obtained from the date of enrollment until the date of completion of the study up to 10 days after enrollment. | Hematocrit will be determined from whole blood samples after each 3-day dietary condition. |
Countries
United States
Outcome results
None listed