Sarcoma,Soft Tissue
Conditions
Brief summary
The goal of this interventional study is to compare sensitivity of regular chest x-ray to ultra-low-dose computed tomography to find pulmonary relapse in follow-up of soft tissue sarcoma. The main question\[s\] it aims to answer are: * Is ultra-low-dose computed tomography more sensitive than regular chest x-ray to find pulmonary relapse? * Does ultra-low-dose computed tomography detect the most fast-growing pulmonary metastases earlier than regular chest x-ray? Participants will have seven ultra-low-dose computed tomography imagings in addition to simultaneous routine protocol of chest x-rays. Participants therefore work as their own controls.
Detailed description
After primary treatment with curative intent for soft tissue sarcoma, patients fulfilling the inclusion criteria and giving informed consent are enrolled. In study protocol patients have their regular chest x-ray once in two months plus ultra-low-dose computed tomography imaging is repeated seven times during the first two years of follow-up. After two years patients without detectable metastases continue in regular follow-up program. The aims of this prospective comparative study are to investigate whether ultra-low-dose computed tomography is more accurate than chest x-ray in soft tissue sarcoma and especially whether the most fast-growing pulmonary metastases could be detected earlier.
Interventions
DIAGNOSTIC_TESTultra-low-dose computed tomography
7 ultra-low-dose computed tomography imaging
Sponsors
Finnish Cancer Society
Helsinki University Central Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* primary high grade soft tissue sarcoma with no metastases at diagnoses or during treatment and treatment with curative intent.
Exclusion criteria
* metastases at diagnoses or during treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with pulmonary relapse detected by ultra-low-dose CT performed according to a pre-defined schedule | 2 years | — |
| Number of patients with pulmonary relapse detected by chest x-ray performed according to a pre-defined schedule | 2 years | — |
| Number of patients with pulmonary relapse by symptoms | 2 years | Pulmonary relapse based on patient-reported symptoms leading to positive finding in x-ray and or conventional chest CT between two control imaging rounds. |
Countries
Finland
Outcome results
None listed