Alveolar Ridge Enlargement
Conditions
Keywords
Alveolar ridge preservation, Allograft, Toothgraft, Allopast
Brief summary
The primary objective of this study was to compare the efficacy of using allograft, autogenous tooth graft, and beta-tricalcium phosphate for alveolar ridge preservation (ARP) by examining the alveolar ridge height and width at baseline and 3 months after the ARP both clinically and radiographically. The secondary objective was to evaluate the quality of the newly formed bone using histomorphometric analysis.
Detailed description
This randomized controlled clinical trial included thirty patients. ARP was performed using either Allograft (Allograft group n=10), Tooth graft (Toothgraft group n=10), and beta tri-calcium- phosphate (beta tri-calcium group n=10). Changes in alveolar ridge dimensions were evaluated clinically and radiographically using cone beam computed tomography at baseline and 3 months. Core bone biopsy samples were obtained 3 months post-extraction during implant placement for histomorphometric analysis.
Interventions
DRUGToothgraft
Particulate dentin
DRUGAllograft
Mineralized corticocancellous allograft
DRUGAlloplast
Beta tri-calcuim phosphate
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. seeking implant-based restorations after tooth extraction. 2. exhibited no evidence of any significant medical history, measured using Burket's Oral medicine health history questionnaire. 3. exhibited Type I and II sockets
Exclusion criteria
1. nonsmokers. 2. Pregnant and breast-feeding females 3. patients with known contraindications to dental implant surgery (e.g., increased bleeding tendency, history of treatments such as radiotherapy,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical assessment | 3 months | Measure bone height loss in millimeter at baseline and after 3 months was measured using periodontal probe from the stent margin to the alveolar ridge crest at six points. In addition, Bone width loss was calculated by measuring alveolar ridge width buccopalatally in millimeter using a caliper clamp. The measurement was done perpendicular to the tangent of the dental arch at the mid-point of the extraction site approximately 4mm apical to the level of the marginal gingiva of the adjacent teeth. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic assessment | 3 months | Measuring loss in bone height in millimeters between baseline and after 3 months. Loss in bone height was calculated by measuring the distance from the alveolar crest both buccally and palatally to a fixed anatomical landmark. In addition, |
Other
| Measure | Time frame | Description |
|---|---|---|
| Histological | 3 months | Masson trichrome special stain was used to detect the area percentage of immature collagen and mature collagen at magnification 20X. The immature collagen appeared blue in color while areas with mature collagen appeared reddish in color |
| Histomorphometric analysis | 3 months | Photomicrographs of 3 microscopic fields of each MT stained section, were captured at the original magnification of 20X using a digital camera(Canon EOS 650D) mounted on a light microscope(BX60,Olympus , Japan). The images were analyzed for obtaining the area percentage of mature and immature collagen of the newly formed bone using image J (1.41aNIH, USA)software |
Countries
Egypt
Outcome results
None listed