Pain
Conditions
Keywords
Pediatric circumcision, Mode of administration, Day surgery, Esketamine
Brief summary
To explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.
Detailed description
The current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.
Interventions
DRUGEsketamine of single injection
Single group: give esketamine 0.75 mg/kg at the time of induction
DRUGEsketamine of Intermittent injection
Intermittent group: give esketamine 0.5mg/kg during anesthesia induction, and during the measuring ring esketamine 0.25mg/kg was given again
Sponsors
Yangzhou University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
6 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists (ASA) class I and II children * Age 5-12 years * Foreskin cerclage is proposed * No history of upper respiratory tract infection in the past two weeks * Obtain the consent of the child's family
Exclusion criteria
* Hepatic and renal insufficiency, coagulation dysfunction * Those who are allergic to esketamine * History of cognitive impairment * epilepsy * other psychiatric and neurological disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| One-time success rate of anesthesia | During surgery | No movement during anesthesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diastolic blood pressure | During surgery | Diastolic blood pressure |
| Heart rate | During surgery | Heart rate |
| intraoperative propofol dosage, esketamine dosage | During surgery | intraoperative propofol dosage, esketamine dosage |
| Duration of surgery | During surgery | Duration of surgery |
| Systolic blood pressure | During surgery | Systolic blood pressure |
| Time to talk | During surgery | Time to talk |
| VAS(visual analogue scale) score | 12 hours after the end of surgery | A score to assess pain, use a swimming ruler about 10 cm long, marked with 10 scales on one side, with 0 and 10 ends at each end, 0 points means no pain, and 10 points represent the most severe pain that is unbearable. |
| Incidence of adverse effects (hypotension, hypertension, respiratory depression, postoperative pain, diplopia, mania) | 12 hours after the end of surgery | Incidence of adverse effects (hypotension, hypertension, respiratory depression, postoperative pain, diplopia, mania) |
| Time to open eyes | During surgery | Time to open eyes |
Outcome results
None listed