Birth Weight, Congenital Malformation, Diabetes, Gestational, Hypertension in Pregnancy, Large for Gestational Age at Delivery (Macrosomia), Preeclampsia, Small for Gestational Age at Delivery
Conditions
Brief summary
The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.
Interventions
OTHERPer- and polyfluoroalkyl substances (PFAS)
Assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register based cohort.
Sponsors
The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)
The Swedish Research Council
Statistics Sweden
National Board of Health and Welfare, Sweden
Swedish University of Agricultural Sciences
Swedish Food Agency
Karolinska Institutet
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Pregnant women residing in Swedish localities with a population exceeding 10,000 inhabitants and giving birth during 2012-2018
Exclusion criteria
* Lack of data of PFAS levels in municipal drinking water (entire localities excluded) * Mothers not living in the study area consistently between first trimester and four years prior to birth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Birth outcome - birthweight | at birth | grams as measured at birth |
| Birth outcome - Small for gestational age (SGA) | at birth | \<-2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848) |
| Birth outcome - Large for gestational age (LGA) | at birth | \>2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848) |
| Birth outcome - major congenital malformations | at birth | ICD10- codes: Q00-Q99 within the first 28 days postpartum, categorized as major congenital malformations according to European Surveillance of Congenital Anomalies (EUROCAT 2014) |
| Maternal health - Gestational hypertension/preeclampsia | during gestation | ICD10-codes: O13-O14. Diagnosis at maternal or primary care |
| Maternal health - Gestational diabetes mellus | during gestation | ICD10-codes: O24 (excluding pregestational diabetes). Diagnosis at maternal or primary care |
Outcome results
None listed