Aberrant Myeloid Lineage Differentiation in HIV/AIDS Patients

A Single-center, Retrospective Cohort Study of Aberrant Myeloid Lineage Differentiation in HIV/AIDS Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05808803

Enrollment

782

Registered

2023-04-11

Start date

2016-01-01

Completion date

2022-01-31

Last updated

2023-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV Infections, Leukemia

Brief summary

The investigators included 782 HIV-infected patients from January 2016 to October 2020 Zhongnan Hospital of Wuhan University, whose AIDS diagnosis criteria met the AIDS Diagnosis and Treatment Guide (2018 edition) of Chinese Medical Association.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* HIV-infection

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
The proportion of granulocytes and granulocyte/macrophage progenitors in myelogram of HIV/AIDS patients	2020	Flow cytometric immunophenotyping of an EDTA-anticoagulated BM aspirate specimen was performed. A standard BM assay with erythrocyte cell lysis was used for all BM aspirate specimens. Flow cytometric analysis was conducted using a FACS Canto II flow cytometer (Becton Dickinson, Sunnyvale, CA, USA).

Secondary

Measure	Time frame	Description
Neutrophil counts in peripheral blood of HIV/AIDS patients	2020	Blood samples were drawn from patients undergoing routine diagnostic blood analysis at our institute by sterile venipuncture into tubes containing 5.4 mg of K2EDTA and analyzed by the automated hematology analyzer.

Outcome results