Hypogonadotropic Hypogonadism
Conditions
Brief summary
The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
Interventions
BEHAVIORAL5-day controlled metabolic dietary intake
Over 5-days, all food will be provided from the metabolic kitchen and participants will be instructed to eat all of the food provided each day and only the food provided each day.
Sponsors
University of Colorado, Denver
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Female * Age 18-30 * Body mass index between 18.5-24.9 OR 30-45 * Have regular menstrual cycles between 18-40 days over the past 6 months * Weight stable (not gained or lost 5kg) in the past 3 months
Exclusion criteria
* Using hormonal birth control currently or within the past three months * Polycystic ovary syndrome (current or past diagnosis) * Pregnant, lactating, planning to become pregnant in next 6 months * Engaging in regular intentional aerobic exercise * Significant medical issues (e.g.,cardiovascular disease or diabetes)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in stimulated pituitary function, as measured by Luteinizing hormone (LH) area under the curve (AUC) over two hours following pituitary stimulation with a physiologic bolus intravenous dose of gonadorelin acetate | Baseline, ~4-weeks, ~8-weeks (visits timed to to days 1-5 of the menstrual cycle) | Within-participant changes in response to both conditions will be measured, with lower LH AUC indicating a blunted pituitary response to stimulation. |
Countries
United States
Contacts
Primary ContactTrish Coordinator, MS, RD
Outcome results
None listed